From discovery to diagnostics: iCura’s cutting-edge spatial biology platforms accelerate research and development, paving the way for personalized medicine and targeted therapies.
Akoya Bioscience’s PhenoImager HT (Ver. 2.0)
Automated high-throughput multiplex immunofluorescence (mIF/IHC) platform for precise biomarker analysis.
Combined with Leica BOND RX, the PhenoImager HT with the most recent software package canprovide high-throughput staining and scanning, up to 80 slides staining and 200 slides scanning in 24 hours.
Brightfield and fluorescence capabilities. Integrated InForm 3.0 image analysis software.
mIF Panels
Akoya MOTiF Melanoma kit: S100 /Sox10, CD8, CD68, FoxP3, PD -l, PD -L1
TME panel: CD25, CD8, FoxP3, PD -L1, Granzyme B
Hodgkin’s Lymphoma, including CD30, CD15, Pax -5, CD20, and MUM – 1
Glioblastoma microenvironment panel: BRAF600E, Sox2, TMEM119, CD68, CD163, pERK
T cell and Macrophage for TME: CD4, CD8, Ki -67, Granzyme B, iNOS, CD68, CD163, PanCK (AE1 /AE3)
Dendritic Cells and Myeloid Derived Suppressor Cells: CD11c, CD11b, CD123, HLA -DR, CD14, CD15, PanCK (AE1 /AE3 )
Custom panels are designed upon client’s request
Phenocode Panels
Immuno-Contexture Human Protein Panel: CD8, CD68, PD-L1, FoxP3, PanCK
Immune Profile Human Protein Panel: CD8, CD3e, CD68, CD20, PanCK
Activated TIL Status Human Protein Panel: CD8, CD3e, Ki67, Granzyme B, PanCK
M1/M2 Polarized Human Protein Panel: CD8, CD68, CD163, PD-1, PD-L1
T Cell Status Human Protein Panel: CD8, CD4, CD20, FoxP3, PD-1
Leica BOND RX
Offers automated staining for IHC, IF, and ISH, with flexibility of customized protocols, used for RUO and LDT purposes.
Processes 30 to 60 slides per instrument in 24 hours depending on protocol.
NextSeq 2000
High-throughput sequencing: Generates large amounts of data in a short time.
Flexible: Handles various applications like RNA-seq, whole exome sequencing, targeted sequencing.
Scalable: Accommodates different run sizes.
Qiagen Qiacuity ndPCR
Digital PCR based on Nano-Plate technology. A highly sensitive quantitative assay with an efficient workflow. Provides absolute quantification (no standard curve required) and multiplexing capabilities.
A powerful tool for detecting extremely low levels of nucleic acid (e.g., cfDNA) and supporting cell and gene therapy development processes.